Accelerated Healing of Chronic Sickle-cell Leg Ulcers Treated With RGD Peptide Matrix

Accelerated healing of chronic sickle-cell leg ulcers treated with RGD peptide matrix. RGD Study Group.

Leg ulcers are a chronic manifestation of sickle-cell disease (SCD) and are often painful, disabling, and difficult to treat. RGD peptide matrix treatment is a novel therapy designed to provide a topical synthetic extracellular matrix that can act as a temporary substitute for the damaged natural matrix at the ulcer site. In this randomized, placebo-controlled, double-blind, prospective, multic...

Interventions for treating leg ulcers in people with sickle cell disease.

BACKGROUND The frequency of skin ulceration makes it an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cell disease. OBJECTIVES To assess the clinical effectiveness and safety of interventio...

Successful Management of a Chronic Refractory Leg Ulcer in an Adolescent with Sickle Cell Anemia.

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by a wide range of clinical manifestations. Chronic leg ulcers are a disabling complication with repercussions on the quality of life. We report the case of a 14-year-old girl with a diagnosis of SCD who developed a chronic leg ulcer that was successfully treated with a multi-disciplinary approach, including local and syst...

Rapid healing of chronic leg ulcers during arginine butyrate therapy in patients with sickle cell disease and thalassemia.

Blood hypercoagulability as a risk factor for leg ulcers in sickle cell disease.

We found the article by Koshy et al,’ entitled “Leg Ulcers in Patients With Sickle Cell Disease” very interesting. However, we want to make some comments mainly addressed to the factors implicated in the development of leg ulcers in sickle cell disease that, in our opinion, bring insights into the pathogenic mechanism of this complication. Among the contributing factors, the authors refer to ‘‘...